The Metabolism of Pantothenic Acid

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The metabolism of pantothenic acid.

The formulation of this pathway was based on: (a) the finding that cysteine supplies the sulfur-containing moiety of CoA (3,4); (b) the activities of pantetheine and pantothenylcysteine as growth factors for Acetobacter suboxydans (4-6) and Lactobacillus helveticus (7); (c) the presence of enzymes in these two organisms and also in Lactobacillus bulgur&s which decarboxylate pantothenylcysteine ...

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Antagonism of L(-)pantothenic acid on lipid metabolism in animals.

The inhibition rate of L(-)pantothenate as an antagonist of D(+)pantothenate was discussed from the viewpoint of growth and lipid metabolism. The growth rate of mice given pantothenate-deficient diets containing L(-)pantothenate (300 mg per 100g diet) was markedly decreased, and such pantothenate-deficient symptoms as "spectacle eyes" appeared. However, it was recovered by the simultaneous addi...

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The effects of high dietary supplements of copper sulphate on pantothenic acid metabolism in the chick.

1. The effects of incorporation of copper sulphate supplying 250 mg copper/kg semi-purified diet with graded amounts of calcium pantothenate (CaPa) were studied in chicks. 2. When the doses of CaPa were marginally adequate or less the Cu supplementation induced severe signs of pantothenic acid (PaA) deficiency. 3. Livers of the Cu-treated birds given low doses of PaA had lower concentrations of...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1959

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)70307-4